Symbol
Name
ID

Coro1a
coronin, actin binding protein 1A
MGI:1345961

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine	Complete or near-complete absence of specific antibody response to tetanus vaccine	Lymphopenia	Recurrent upper respiratory tract infections	Recurrent otitis media	Chronic oral candidiasis	Immunodeficiency	Post-vaccination varicella zoster virus infection	Recurrent lower respiratory tract infections
Disease(s) Associated with CORO1A
coronin-1A deficiency

Mouse Phenotypes

increased T cell apoptosis

abnormal leukocyte migration

decreased T cell proliferation

increased mast cell degranulation

impaired macrophage phagocytosis

decreased thymocyte number

increased thymocyte number

abnormal thymocyte activation

enlarged spleen

increased spleen weight

decreased B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased memory T cell number

decreased T cell number

decreased monocyte cell number

abnormal effector T cell morphology

decreased spleen weight

abnormal T cell physiology

abnormal T cell activation

enlarged lymph nodes

small lymph nodes

decreased interleukin-2 secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

decreased susceptibility to systemic lupus erythematosus

increased susceptibility to systemic lupus erythematosus

decreased autoantibody level

glomerulonephritis

decreased susceptibility to bacterial infection

Availability

Mouse Genotype

Coro1a^koy/Coro1a^koy

Coro1a^{Lmb3-C57BL/6Scr}/Coro1a^{Lmb3-C57BL/6Scr}

Coro1a^{Lmb3-MRL/MpScr}/Coro1a^{Lmb3-MRL/MpScr}

Coro1a^ptcd/Coro1a^ptcd

Coro1a^tm1Achn/Coro1a^tm1Achn

Coro1a^tm1Jpie/Coro1a^tm1Jpie

Coro1a^ptcd/Coro1a^tm1Achn

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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